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. 2020 Aug 21;8:771. doi: 10.3389/fcell.2020.00771

FIGURE 7.

FIGURE 7

CXCR4 expressing cells in the palatal osteogenic centers. (A) Upper panel: Fluorescent immunohistochemical-stained coronal palatal section for CXCR4 expression (green), representative for the wt E15 and HO-2 KO E15, e.g., HO-2 KO. Middle panel: Within the disintegrating MES almost no CXCR4 expressing cells were found. Green panel: Near the forming nasal septum clusters of strong CXCR4 expressing cells were found. Also within the cartilage of the forming nasal septum CXCR4 expressing cells were present. Red panel: The osteogenic centers in the lateral parts of the fusing palate demonstrated clusters of strong CXCR4 expressing cells. (B) Upper panel: Fluorescent immunohistochemical stained coronal palatal section for CXCR4 expression (green), representative for the wt CD1 E16 and wt CD1 SnMP E16 fetuses, e.g., wt CD1 SnMP E16. Middle panel: in the osteogenic centers in the central part of the fusing palate clusters of CXCR4-positive-stained mesenchymal cells were found. Green panel: Near the forming nasal septum clusters of strong CXCR4 expressing cells were found. Also within the cartilage of the forming nasal septum CXCR4 expressing cells were present. Red panel: The osteogenic centers in the lateral parts of the fusing palate demonstrated clusters of strong CXCR4 expressing cells.