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. 2020 Aug 21;8:771. doi: 10.3389/fcell.2020.00771

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Copyright © 2020 Verheijen, Suttorp, van Rheden, Regan, Helmich, Kuijpers-Jagtman and Wagener.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HO-1 expressing cells in the palatal osteogenic centers. (A) Upper panel: Fluorescent histochemical stained coronal palatal section for HO-1 expression (green), representative for the wt E15 and HO-2 KO E15 fetuses, e.g., HO-2 KO E15. Middle panel: In the mesenchyme near the disintegrating MES some HO-1 expressing cells (white arrow) were found. Green panel: Near the forming nasal septum clusters of strong HO-1 expressing cells were found. Red panel: The osteogenic centers in the lateral parts of the fusing palate demonstrated clusters of strong HO-1 expressing cells. (B) Upper panel: Fluorescent histochemical-stained coronal palatal section for HO-1 expression (green), representative for the wt CD1 E16 and wt CD1 SnMP E16 fetuses. Middle panel: In the central part of the fusing palate some HO-1 expressing cells were found. Green panel: Near the forming nasal septum clusters of strong HO-1 expressing cells were found. Red panel: The osteogenic centers in the lateral parts of the fusing palate demonstrated clusters of strong HO-1 expressing cells.