Table 1.

List of all Metabolites Altered by ETOM (100 μM) Treatment with Regard to Fractional Contribution for HK157

TCA Cycle	Pentose Phosphate	Nucleotide Metabolism	Amino Acid Metabolism	Fatty Acid/Lipid Metabolism	Currency	Other
Aconitate	S-Adenosyl methionine	5-Methylthio adenosine	L-Asparagine	O-Acetylcarnitine	Acetyl-CoA	D-Glucosamine 6-phosphatea
Citrate		Adenosine triphosphate	L-Aspartic acid	Cytidine diphosphate	Adenosine triphosphate	Hydroxymethylglutaryl-CoA
Fumarate		Cytidine	L-Proline	Cytidine diphosphate ethanolamine	Reduced glutathione
Lactate		Cytidine monophosphate	3-Phosphoserine		Oxidized glutathione
Malate		Cytidine triphosphate
Succinate		Cytosine
L-Glutamine		Hypoxanthine
L-Glutamate		Orotidine
		Uridine diphosphate
		Uridine diphosphate glucose
		UDP-N-acetylglucosamine

Metabolites were measured by labeled ¹³C-palmitic acid using LC-MS analysis (p < 0.05 for all metabolites listed).

^aIndicates an increase with ETOM treatment.