Table 3.

List of all Metabolites Altered by ETOM (100 μM) Treatment with Regard to Fractional Contribution for IDH1 Mutant HK252

TCA Cycle	Nucleotide Metabolism	Amino Acid Metabolism	Fatty Acid/Lipid Metabolism	Currency	Other
Aconitate	Adenosine	L-Asparagine	O-Acetylcarnitine	Acetyl-CoA	N-Acetyl-D-glucosamine 6-phosphate
Citrate	Adenine	L-Aspartic acid	Cytidine diphosphate	Adenosine triphosphate
Malate	Adenosine triphosphate	L-Argininea	Cytidine diphosphate ethanolamine	Reduced Glutathione
Succinate	Cytidine	Homocysteine		Oxidized Glutathione
2-Hydroxyglutarate	Cytidine monophosphate	L-Proline
L-Glutamine	Cytidine triphosphate
L-Glutamate	Cytosine
	Deoxyguanosine
	Inosine
	Orotidine
	Uridine diphosphate
	Uridine diphosphate glucose
	UDP-N-acetylglucosamine
	Uridine monophosphate
	Uridine triphosphate

Metabolites were measured by labeled ¹³C-palmitic acid using LC-MS analysis (p < 0.05 for all metabolites listed).

^aIndicates an increase with ETOM treatment.