Figure 1.

Experimental design. Rats were submitted to a stereotaxic surgery with the injection of Aβ or saline solution (sham surgery) in the hippocampus. Ten days after surgery, the time required for surgery recovery and Aβ aggregation, the training period started, being: physical exercise (PE), cognitive exercise (CE), or none (no intervention), during 4 weeks. Afterward, behavioral tests were performed to evaluate the object and social recognition memory and to monitor the general behavioral; after, the euthanasia was performed to brain tissue collection for histological and biochemical analyses. OR, object recognition memory test; SR, social recognition memory test; OF, open field; PM, plus maze.