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. 2020 Aug 21;8:763. doi: 10.3389/fcell.2020.00763

FIGURE 1.

FIGURE 1

Transcript levels of MECP2E1, MECP2E2, BDNF, and miR132. In all studied brain regions of three RTT (B,E) and controls (A,D), MECP2E1 and miR132-3P are significantly higher than MECP2E2 and miR132-5P, respectively. Cerebellum in comparison with the other three brain regions shows the highest level for all the studied transcripts except for microRNA132 (A,B,D,E,G,H). Rett Syndrome (RTT) patients show lower transcript levels of MECP2E1, MECP2E2, BDNF, miR132-3P, and miR132-5P in four studied brain regions compared to their age-, and sex- matched controls (C,F,I). Cerebellum has exceptionally similar level of miRNAs in RTT and controls (F). Frontal cerebrum (Fc), Hippocampus (Hp), Amygdala (Am), Cerebellum (Cb); N = 3 ± Standard Error of the Mean (SEM); One-way ANOVA with multiple pairwise comparisons used among different brain regions. Student’s t-test was used to compare controls and RTT samples for each parameter. The significance level was determined at single symbol P < 0.05, double symbols P < 0.01, triple symbols P < 0.001, and quadruple symbols P < 0.0001.