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. 2020 Aug 21;8:763. doi: 10.3389/fcell.2020.00763

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Copyright © 2020 Pejhan, Del Bigio and Rastegar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathologic studies of different brain regions in three Rett Syndrome (RTT) patients and their sex-, and age-matched controls stained by Hematoxylin and Eosin (H&E). There were not noticeable findings at the microscopic levels. Two subtle changes are shown here: small pyramidal neurons and increased cell density in hippocampal region of T158M brain (A4) compared to the control (A3); thin and hypocellular dentate gyrus in the hippocampus of A201V brain (black arrow in B4) compared to the control (B3); Control (CRL); Year old (Y); 200× magnification.