Table IV.

Validation of the prognostic value of EDNRB.

Variable	iAUC	C-index (95% CI)	IDI for 3 years	P1	IDI for 5 years	P2
Model 1	0.74	0.69 (0.61–0.76)	0.04	0.02	0.05	0.01
Model 2	0.78	0.73 (0.65–0.81)

iAUC, integrated area under the curve of time-dependent ROC; C-index, concordance index; CI, confidence interval; IDI, integrated discrimination improvement. The P-value reflects the IDI test results of 3 and 5 years. Model 1 consists of N stage and NAC; Model 2 consists of N stage, NAC and EDNRB expression.