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The effect of cancer treatment on cfDNA levels.
| First therapy | Treatment/s | cfDNA (ng/ml), median (95% CI) | n | p-value | |
|---|---|---|---|---|---|
| Before biopsy | After treatment | ||||
| Surgery | Tumor resection | 456 (304–683) | 285 (153–400) | 27 | 0.01 |
| Surgery | Resection + radiation | 446 (278–840) | 258 (29–375) | 12 | 0.006 |
| Neoadjuvant | Chemotherapy | 816 (549–1,300) | 310 (26–551) | 5 | 0.06 |
| Neoadjuvant | Chemotherapy + resection | 653 (412–929) | 243 (0–344) | 6 | 0.03 |
| Surgery + neoadjuvant | End of therapy | 525 (394–708) | 251 (198–290) | 28 | 0.003 |
