Table 3.
Area under the ROC curves, cut-off value, sensitivity, and specificity in CD and UC patients.
| Cytokine | AUC | Sensitivity (%) | Specificity | Cut-off value (pg/mL) | p-value |
|---|---|---|---|---|---|
| (A) | |||||
| IL-7 | 0.94 | 88 | 86 | 5.00 | < 0.001 |
| IL-13 | 0.89 | 100 | 86 | 3.00 | < 0.05 |
| VEGF | 0.88 | 100 | 86 | 40.00 | < 0.05 |
| IL-6 | 0.88 | 63 | 100 | 6.50 | < 0.01 |
| (B) | |||||
| IL-7, IL-6 | 0.90 | 63 | 100 | < 0.001 | |
| IL-13, IL-7 | 0.87 | 86 | 88 | < 0.001 | |
| IL-13, IL-6 | 0.85 | 63 | 100 | < 0.001 | |
| IL-7, VEGF | 0.74 | 86 | 88 | < 0.05 | |
| VEGF, IL-6 | 0.74 | 63 | 100 | < 0.05 | |
| IL-13, VEGF | 0.73 | 86 | 88 | ns | |
| (C) | |||||
| IL-13, VEGF, IL-6 | 0.88 | 50 | 86 | < 0.001 | |
| IL-13, IL-7, IL-6 | 0.88 | 50 | 86 | < 0.001 | |
| IL-7, VEGF, IL-6 | 0.76 | 75 | 86 | < 0.01 | |
| IL-13, IL-7, VEGF | 0.74 | 86 | 88 | ns | |
| (D) | |||||
| IL-13, IL-7, VEGF, IL-6 | 0.76 | 84 | 93 | < 0.05 | |
ROC receiver operating characteristic, CD Crohn’s disease, UC ulcerative colitis, AUC area under the curve, IL interleukin, VEGF vascular endothelial growth factor.