Table II.

Pro-apoptotic activity of isoxazole derivatives 1–11 in K562 cells.

Sample	Early apoptosis,%	Late apoptosis,%	Total apoptosis,%
Untreated cells (−)	0.10	0.10	0.20
1 (50 nM)	14.00	27.21	41.21
1 (100 nM)	16.15	30.30	46.45
2 (10 nM)	4.15	2.15	6.30
2 (20 nM)	20.46	10.26	30.72
3 (50 nM)	29.45	6.70	36.15
3 (100 nM)	28.75	10.00	38.75
4 (100 nM)	25.75	7.80	33.55
4 (200 nM)	64.90	15.20	80.10
5 (50 nM)	23.60	6.60	30.20
5 (100 nM)	31.90	11.95	43.85
6 (50 nM)	30.30	6.40	36.70
6 (100 nM)	25.85	16.00	41.85
7 (1 µM)	36.40	10.40	46.80
7 (5 µM)	37.55	24.80	62.35
8 (5 µM)	30.30	15.55	45.85
8 (10 µM)	54.05	36.55	90.60
9 (1 µM)	44.90	13.25	58.15
9 (5 µM)	39.85	24.45	64.30
10 (50 µM)	15.40	2.70	18.10
10 (100 µM)	23.75	16.70	40.45
11 (100 µM)	39.40	17.30	56.70
11 (200 µM)	63.45	25.05	88.50