Table IV.

Pro-apoptotic activity of isoxazole derivatives 1–11 in T98G cells.

Samples	Early apoptosis,%	Late apoptosis,%	Total apoptosis,%
Untreated cells (−)	6.95	2.25	9.20
1 (50 nM)	3.63	2.46	6.09
1 (100 nM)	4.83	8.44	13.27
2 (10 nM)	4.65	2.56	7.21
2 (20 nM)	2.35	2.57	4.92
3 (50 nM)	32.60	7.90	40.50
3 (100 nM)	37.50	11.00	48.50
4 (100 nM)	32.55	6.25	38.80
4 (200 nM)	36.20	10.60	46.80
5 (50 nM)	29.30	3.85	33.15
5 (100 nM)	34.05	8.65	42.70
6 (50 nM)	15.50	1.65	17.15
6 (100 nM)	13.30	3.95	17.25
7 (1 µM)	6.90	2.30	9.20
7 (5 µM)	13.60	3.15	16.75
8 (5 µM)	8.55	2.20	10.75
8 (10 µM)	13.65	5.45	19.10
9 (1 µM)	28.15	13.65	41.80
9 (5 µM)	36.95	11.95	48.90
10 (50 µM)	9.20	3.35	12.55
10 (100 µM)	17.75	8.65	26.40
11 (100 µM)	6.10	1.85	7.95
11 (200 µM)	12.35	3.15	15.50