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. 2020 Sep 3;10:14598. doi: 10.1038/s41598-020-71548-z

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© The Author(s) 2020, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Development of human skin and lymphoid tissues in the human Skin and Immune System-humanized NSG mouse model. Transplantation of full-thickness human skin (derived from the scalp for skin with hair, or derived from dorsum for skin without hair) on the dorsum (A, B) and autologous lymphoid tissues in the kidney capsule (C) of NSG mice results in the engraftment and development of full-thickness human skin and lymphoid tissues. (A) Representative gross-photos at 0 (the day of transplantation), 2-, 4- and 10-weeks post-transplantation, with intact mouse skin as control (n = 4 per group). (B) Transplantation of full-thickness human skin from regions with significant hair follicles (scalp) in the human Skin and Immune System-humanized NSG mouse model results in the development of human hair, as exhibited in representative gross-photos at 12 weeks post-transplantation (n = 6). (C) Representative gross-photos of human lymphoid tissues (spleen and thymus tissues) and humanized lymphoid tissues (reconstituted-immunodeficient murine lymph node and spleen) at ten weeks post-transplantation (n = 4).