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. 2020 Sep 3;10:14598. doi: 10.1038/s41598-020-71548-z

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© The Author(s) 2020, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Development of human skin and lymphoid tissues in the human Skin and Immune System-humanized SRG rat model. Transplantation of full-thickness human fetal skin on the dorsum (A, B) and autologous fetal lymphoid tissues (thymus and liver) in the kidney capsule (C) of SRG rats results in engraftment and development of full-thickness human skin and primary lymphoid tissue (thymus) (n = 4). (A) Representative gross-photos at 0- (the day of transplantation), 3-, 20-, and 36-weeks post-transplantation demonstrate human fetal skin engraftment and development (using donor skin obtained from the dorsum). (B) Transplantation of full-thickness human fetal skin, derived from regions with significant hair follicles (scalp), on SRG rats with (left panel) (n = 2) or without (right panel) (n = 2) co-transplantation of thymus and hematopoietic stem cells results in the development of human hair as exhibited in representative gross-photos at six months post-transplantation. In the right panel, autologous human skin from dorsum and scalp were co-transplanted to demonstrate human hair only grows in human skin tissue with preexisting hair follicles (scalp; identified with black box). (C) Representative gross-photos of lymphoid tissues (human thymus in the kidney capsule and rat spleen) at nine months post-transplantation demonstrates the development of lymphoid tissues compared to non-transplanted SRG rat (n = 4). The black circles denote human thymus tissues.