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. 2020 Sep 3;10:14598. doi: 10.1038/s41598-020-71548-z

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© The Author(s) 2020, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Human skin xenograft on SRG rats supports CA-MRSA infection. Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) was inoculated into human skin xenograft (intradermal injection) on humanized (human skin) SRG rats (n = 9) to demonstrate that the human skin xenograft supports CA-MRSA infection. (A) Gross analysis of the skin tissues were examined in CA-MRSA inoculated humanized (human skin) SRG rats (n = 9) and compared to CA-MRSA infected human skin (Patient CA-MRSA skin photo credit: S. Camazine); healthy control-human skin in humanized (human skin) SRG rats (n = 5) were also used as controls to determine skin lesions. (C) The skin lesions in the CA-MRSA inoculated humanized (human skin) SRG rats (n = 9) supports high CA-MRSA bacteria load as measured at six weeks post-infection.