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. 2020 Aug 21;10:1378. doi: 10.3389/fonc.2020.01378

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Copyright © 2020 Liu, Xu, Liang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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3,4-Methylenedioxy-β-nitrostyrene (MNS) downregulates the expression level of nucleotide-binding domain, leucine-rich family, and pyrin-containing 3 (NLRP3) inflammasome. (A) Western blot analyses of NLRP3 inflammasome and interleukin (IL)-1β protein expression in SW1990 and PANC-1 cells treated with two different concentrations of MNS for 12 h. (B) Relative quantitation of NLRP3 inflammasome and IL-1β. The results showed a significant decrease in the expression of NLRP3 inflammasome of PANC-1 and SW1990 cells treated with MNS (10 and 20 μM) compared with the non-treated control cells. *P < 0.05; **P < 0.01.