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. 2020 Aug 21;10:1378. doi: 10.3389/fonc.2020.01378

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Copyright © 2020 Liu, Xu, Liang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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3,4-Methylenedioxy-β-nitrostyrene (MNS) inhibits the migration and invasion of pancreatic cancer cells. (A,B) The migration of cells into the wound was monitored in multiple wells. The images were acquired every hour for 20 h. The images shown represent 0, 12, 15, and 72 h. The distance between the two edges of the scratch in the MNS-treated cells was greater than that of the control. (C,D) MNS inhibits cell migration and invasion of PANC-1 and SW1990 in Transwell assay. Representative images are shown (×100 magnification). (E,F) Quantification of migration and invasion in Transwell assay. The values shown are expressed as the mean ± SEM. **P < 0.01 vs. non-MNS-treated control group.