Table I.

Results of somatic alteration profiles identified by the Oncomine focus assay in 22 patients with advanced gastric cancer.

Sample	Gene	Transcript	Base change	Codon change	Effect	Freq %	COSMIC ID	dbSNP
CN03	ERBB2	NM_004448.3	c.2524G>A	p.Val842Ile	Missense	10	COSM14065	rs1057519738
CN11	EGFR	NM_005228.4	c.2227G>A	p.Ala743Thr	Missense	22	–	rs759256622
CN11	KRAS	NM_033360.3	c.38G>A	p.Gly13Asp	Missense	47	COSM532	rs112445441
CN13	FGFR3	NM_000142.4	c.274delC	p.Gln92Serfs*6	Frameshift	28	–	–
CN14	ALK	NM_004304.4	c.4061G>T	p.Cys1354Phe	Missense	16	–	rs963770969
CN15	PIK3CA	NM_006218.3	c.328_330delGAA	p.Glu109del	Frameshift	41	COSM24710	rs1060500031
CN16	PIK3CA	NM_006218.3	c.323G>A	p.Arg108His	Missense	27	COSM27497	rs886042002
CN23	PIK3CA	NM_006218.3	c.328_330delGAA	p.Glu109del	Frameshift	20	COSM24710	–
CN27	ERBB2	NM_004448.3	c.2033G>A	p.Arg678Gln	Missense	9	COSM436498	rs1057519862
CN28	PIK3CA	NM_006218.3	c.1633G>A	p.Glu545Lys	Missense	8	COSM763	rs104886003
CN34	CTNNB1	NM_001904.3	c.98C>T	p.Ser33Phe	Missense	6	COSM5669	rs121913400
CN38	FGFR1	NM_001174067.1	c.2359C>T	p.Arg787Cys	Missense	20	–	–
CN40	KRAS	NM_033360.3	c.34G>A	p.Gly12Ser	Missense	24	COSM517	rs121913530
	PIK3CA	NM_006218.3	c.1633G>A	p.Glu545Lys	Missense	7	COSM763	rs104886003
CN44	FGFR3	NM_000142.4	c.274delC	p.Gln92Serfs*6	Frameshift	18	–	–
	PIK3CA	NM_006218.3	c.1390T>G	p.Ser464Ala	Missense	39	–	–
CN46	PIK3CA	NM_006218.3	c.1633G>A	p.Glu545Lys	Missense	23	COSM763	rs104886003
CN49	BRAF	NM_004333.4	c.1780G>A	p.Asp594Asn	Missense	6	COSM27639	rs397516896

dbSNP, database for single nucleotide polymorphisms; freq, mutation frequency.