Table III.
Comparison of clinicopathologic findings according to Lauren's classification subtypes in 50 patients with advanced gastric cancer.
| Characteristic | Diffuse (n=15) | Intestinal (n=30) | Mixed (n=5) | P-value |
|---|---|---|---|---|
| Male | 8 (53%) | 24 (80%) | 4 (80%) | 0.138 |
| Age, years (range) | 62 (39–91) | 71 (52–89) | 56 (53–59) | 0.003 |
| Differentiation | <0.001 | |||
| Moderate | 0 (0%) | 24 (80%) | 1 (20%) | |
| Poor | 15 (100%) | 6 (20%) | 4 (80%) | |
| TNM T stage | 0.830 | |||
| 2 | 1 (7%) | 3 (10%) | 0 (0%) | |
| 3 | 3 (20%) | 9 (30%) | 1 (20%) | |
| 4a | 11 (73%) | 18 (60%) | 4 (80%) | |
| TNM N stage | 0.378 | |||
| 0 | 3 (20%) | 7 (23%) | 0 (0%) | |
| 1 | 1 (7%) | 9 (30%) | 1 (20%) | |
| 2 | 4 (27%) | 7 (23%) | 1 (20%) | |
| 3a | 5 (33%) | 7 (23%) | 2 (40%) | |
| 3b | 2 (13%) | 0 (0%) | 1 (20%) | |
| TNM M stage | 0.088 | |||
| 0 | 14 (93%) | 30 (100%) | 4 (80%) | |
| 1 | 1 (7%) | 0 (0%) | 1 (20%) | |
| Any mutations (SNV + indel) | 0.240 | |||
| No | 13 (87%) | 19 (63%) | 3 (60%) | |
| Yes | 2 (13%) | 11 (37%) | 2 (40%) | |
| Any amplifications | 1.000 | |||
| No | 12 (80%) | 24 (80%) | 4 (80%) | |
| Yes | 3 (20%) | 6 (20%) | 1 (20%) | |
| Any mutations or amplifications | 0.522 | |||
| No | 10 (67%) | 16 (53%) | 2 (40%) | |
| Yes | 5 (33%) | 14 (47%) | 3 (60%) |
SNV, single nucleotide variant; indel, small insertion, duplication and deletion; TNM, Tumor-Node-Metastasis (4).