Table III.
Status of Apc and Apc target genes in Apc [−/−] colonic epithelial cells.
| Colonic epithelial cell linea | |||||
|---|---|---|---|---|---|
| Target gene | Apc[+/+] C57 COL | Apc [−/−] 1638N COL | P-value | Apc [−/−] 850 MIN COL | P-value |
| Apc | 17.6±1.7 | Undetectable | Undetectable | ||
| β-catenin | 4.7±0.3 | 8.2±0.5 | 0.020 | 9.0±0.8 | 0.014 |
| Cyclin D1 | 3.0±0.1 | 15.1±1.4 | 0.014 | 16.1±1.5 | 0.020 |
| c-Myc | 2.1±0.2 | 6.8±0.6 | 0.031 | 6.6±0.4 | 0.031 |
| COX-2 | 3.9±0.4 | 14.3±1.6 | 0.020 | 12.8±1.8 | 0.031 |
a
Mean ± SD, N=4 per treatment group. Data are presented as the log mean FU. β-catenin, cyclin D1, c-Myc and COX-2. C57 COL < 1638N COL. C57 COL < 850 MIN COL. Data were analyzed by ANOVA and Dunnet's test (α=0.05). Apc, adenomatous polyposis coli; COX-2, cyclooxygenase; FU, fluorescence units.