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Hypothesized relations among model parameters and cancer hallmarks and TME players. Star parameters are assumed to be individuals' genetic, molecular, or cellular dependency.
| Parameter | Representative hallmark | Hypothesized TME player |
|---|---|---|
| ∗ p 01 | 1, 2, 4, 6, 7, 8, 9 | 1, 2 |
| ∗ p 02 | 1, 2, 4, 6, 7, 8, 9 | 1 |
| ∗ K dT | 8 | 2, 6, 5 |
| ∗ K dI | 1, 2, 3 | 2, 6, 4, 5 |
| ∗ Nmm | 1, 2, 4, 6, 9 | 6 |
| R max | 7 | 6 |
| a | 1, 2 | 6 |
| b | 1, 2 | 6 |
| ∗Age | 1, 2, 4, 6, 9 | 6 |
