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Transcriptional Control by Premature Termination.
Premature transcription termination (PTT) is mutually exclusive with full-length transcription. Independent of the fate or function of prematurely terminated transcripts, PTT negatively regulates the expression of the full-length transcripts. Genes controlled by PTT include transcriptional regulators 48., 68., DNA repair genes [50], and tumour suppressor genes [49], and tend to be larger than average genes 40., 69..
