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. 2020 Aug 21;10:1628. doi: 10.3389/fonc.2020.01628

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Copyright © 2020 Niu, Yan, Guo, Wang, Zhao, Ren, Huang, Zhang, Yu and Liang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of PPI network, analysis of key modules, and identification of hub genes. (A) The whole PPI network. Upregulated genes are marked in red, while the downregulated genes are marked in green. (B) PPI network of module 1. (C) PPI network of module 2. (D) PPI network of module 3. (E) Hub genes were identified by intersection of 50 genes from 10 algorithms including MCC, DMNC, MNC, Degree, EPC, BottleNeck, EcCentricity, Closeness, Radiality, and Betweenness. PPI, protein–protein interaction.