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. 2020 Sep 3;10:14543. doi: 10.1038/s41598-020-71429-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of DNA synthesis catalyzed by ProtoScript II reverse transcriptase on the G-quadruplex containing HT4 RNA template (40 nM) at 42 °C in the presence of 5a–h (80 nM). (A) Autoradiogram of 12% PAA sequencing gel. (B) The bar graph showing the ratio of the radiation corresponding to pausing sites to total radiation of the lane. Data shown are expressed as the mean of two independent experiments; error bars indicate the standard error of the mean. Symbols (*, ***) and (ns) at the top of the bars indicate statistically significant difference (p ≤ 0.1, p ≤ 0.01) and statistically insignificant difference (p > 0.1), respectively. Data obtained for 5a–h were tested against control and only values of p > 0.05 are indicated in the plot.