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. 2020 Aug 26;20(5):17. doi: 10.3892/etm.2020.9144

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Expression of collagen in the progression of renal interstitial fibrosis induced by UUO. (A) Sham operation. Collagen deposition at (B) 3, (C) 7 and (D) 14 days after UUO surgery. (E) Statistical analysis of Sirius-Red positive area. Content of collagen was assessed by Sirius red-staining on sections of rat kidneys. A large amount of collagen was accumulated in the glomerular and tubular interstitial areas, which increased gradually over time. Highest level of collagen was detected at 14 days after surgery. Magnification, x400. All data are presented as the mean ± SEM. n=6. ^**P<0.01 vs. sham group. UUO, unilateral ureteral obstruction.