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. 2020 Aug 26;20(5):17. doi: 10.3892/etm.2020.9144

Figure 4.

Figure 4

Effect of metformin on inflammation of obstructed kidney. (A) Sham operation. (B) UUO rats. (C) UUO rats treated with low-concentration of metformin, 50 mg/kg/day. (D) UUO rats treated with medium-concentration of metformin, 100 mg/kg/day. (E) UUO rats treated with high-concentration of metformin, 200 mg/kg/day. (F) Statistical analysis of CD68 expression. Magnification, x400. All data are presented as the mean ± SEM. n=6. **P<0.01 vs. sham group; ##P<0.01 vs. UUO group. UUO, unilateral ureteral obstruction; IOD, integral optical density.