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. 2020 Aug 26;20(5):17. doi: 10.3892/etm.2020.9144

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of metformin on the expression of Deptor in obstructed kidneys analyzed by immunohistochemistry. Deptor expression in kidneys was investigated in various groups. (A) Sham operation. (B) UUO rats. (C) UUO rats treated with low-concentration metformin, 50 mg/kg/day. (D) UUO rats treated with medium-concentration metformin, 100 mg/kg/day. (E) UUO rats treated with high-concentration metformin, 200 mg/kg/day. (F) Statistical analysis of Deptor immunohistochemistry-positive area. n=6. (G) Protein expression of Deptor in the kidneys of rats was analyzed by western blotting. (H) Statistical analysis of Deptor expression level. Magnification, x400. n=3. All data are presented as the mean ± SEM. ^**P<0.01 vs. sham group; ^#P<0.05, ^##P<0.01 vs. UUO group. UUO, unilateral ureteral obstruction; Deptor, DEP domain-containing mTOR interacting protein; IOD, integral optical density.