TABLE 2.

A summary of the pro-inflammatory reactions in monocultures and multicellular human lung models.

		MDMs			LPS or MP application/in vivo significance	Approach 1			Approach 2			Approach 3			Approach 4
	Treatment	MP10 Ctrl	LPS	LPS + MP10	LPS	Basal/blood-derived inflammation			Apical/inflammation from the airways			Apical/inflammation from the airways			Basal and apical/strong tissue inflammation
Surface marker expression	CD86	0	+	0	MP	Apical/pulmonary drug delivery			Basal/systemic drug administration			Apical/pulmonary drug delivery			Apical/pulmonary drug delivery
Pro-inflammatory mediators secretion	IL-8	0	+++	++		−	++	+	−	+	+	NA	++	+	NA	+	−
	TNF-α	0	+++	++		−	+	+	−	++	+		+	+		+	+
	IL-1β	NA	NA	NA		−	+	+	−	+	+		+	+		+	+
			Pro-inflammatory		CXCL8	−	++	−	−	++	−		++	−		++	−
			gene expression		TNF	−	−	++	−	−	+		+	−		++	−
					IL1B	−	0	0	−	++	+		++	0		+	−