Table 3.
Top genetic polymorphisms associated with log-transformed FGF23 level.
| SNP | Chr | Position | Nearest gene | FGF23 Increasing allele | Other allele | FGF23 increasing allele frequency | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P value | Beta (SEM) | P value | Beta (SEM) | P value | Beta (SEM) | |||||||
| rs17111495 | 1 | 55,500,706 | PCSK9 | G | C | 0.98 | 1.04 × 10–10 | 0.463 (0.071) | 1.57 × 10–10 | 0.458 (0.071) | 1.55 × 10–10 | 0.458 (0.071) |
| rs17843626 | 6 | 32,621,013 | HLA-DQA1 | G | A | 0.49 | 1.80 × 10–8 | 0.117 (0.021) | 1.70 × 10–8 | 0.117 (0.021) | 1.75 × 10–8 | 0.117 (0.021) |
| rs2798631 | 1 | 218,611,878 | TGFB2 | G | A | 0.75 | 4.97 × 10–7 | 0.115 (0.023) | 3.73 × 10–7 | 0.116 (0.023) | 3.71 × 10–7 | 0.116 (0.023) |
Model 1 was adjusted for age, sex and the first ten principal components of ancestry. Model 2 was additionally adjusted for BMI. Model 3 was additionally adjusted for BMI and eGFR. SNP single nucleotide polymorphism; Chr chromosome. rs17111495, rs2798631 and rs17843626 are imputed with high info scores (0.809, 0.997 and 0.990 respectively).