Skip to main content
. 2020 Aug 6;12(8):505. doi: 10.3390/toxins12080505

Table 1.

Selected α-conotoxin sequences showing the conserved disulfide framework.

Conotoxin Sequence Analgesia UniProt ID
graphic file with name toxins-12-00505-i001.jpg
AnIB G G C C S H P A C A A N N Q D Y C * n.r. P0C1V7
AuIB - G C C S Y P P C F A T N P D - C * ✓ P56640
BuIA - G C C S T P P C A V L Y - - - C * ✓ P69657
EpI - G C C S D P R C N M N N P D Y C * n.r. P56638
GI - E C C N - P A C G R H Y S - - C * ✓ P01519
ImI - G C C S D P R C A W R - - - - C * ✗ P50983
Kn1.2 P G C C N N P A C V K H R - - - C G n.r. D4HRK7
MI G R C C H - P A C G K N Y S - - C * ✓ P01521
MII - G C C S N P V C H L E H S N L C * ✓ P56636
MrI.I - G C C S H P A C S V N N P D I C * ✓ Q6PTD1
PeIA - G C C S H P A C S V N H P E L C * ✓ Q1L777
[A10L]-PnIA - G C C S L P P C A L N N P D Y C * n.r. P50984
Pu1.2 G G C C S Y P P C I A N N P L - C * ✓ A1X8D8
Reg1d - G C C S D P R C K H E - - - - C * n.r. P85010
RgIA - G C C S D P R C R Y R - - - - C R ✓ P0C1D0
SI - I C C N - P A C G P K Y S - - C * n.r. P15471
Tx1.2 P Q C C S H P A C N V D H P E I C * n.r. P0DPL9
Vc1.1 - G C C S D P R C N Y D H P E I C * ✓ P69747

Highlighted: invariant cysteine residues, yellow; Loop I proline residues, blue; and serine residues, green. * = C-terminal amide, Y = sulfonated tyrosine, n.r. = not reported.