. 2020 Aug 9;12(8):511. doi: 10.3390/toxins12080511

Table 2.

Treatment emergent adverse events.

Adverse Event	15 µg TTX ^a (%) (Severity/Relationship)		30 µg TTX (%) (Severity/Relationship)		45 µg TTX (%) (Severity/Relationship)		Overall TTX (%)	400 mg ^b Moxifloxacin (%)	Placebo ^c (%)
Total TEAEs ^d	9 (100%)		24 (100%)		46 (100%)		79 (100%)	14 (100%)	8 (100%)
Arthralgia	0		0		1 (2%)		1 (1%)	0	0
Arthralgia	0		0		Mild	Possibly
Back Pain	0		1 (4%)		1 (2%)		2 (3%)	0	0
Back Pain	0		Mild	Unlikely	Moderate	Unlikely
Chest Discomfort	0		0		1 (2%)		1 (1%)	0	0
Chest Discomfort	0		0		Mild	Possibly
Chills	0		0		1 (2%)		1 (1%)	1 (7%)	0
Chills	0		0		Mild	Possibly
Cough	0		1 (4%)		0		1 (1%)	0	0
Cough	0		Mild	Unlikely	0
Dizziness	1 (11%)		3 (13%)		4 (9%)		8 (10%)	2 (14%)	1 (13%)
Dizziness	Mild	Probably	3x Mild	3x Probably	4x Mild	4x Probably
Dry Throat	0		0		1 (2%)		1 (1%)	0	0
Dry Throat	0		0		Mild	Probably
Ear Pruritus	0		1 (4%)		0		1 (1%)	0	0
Ear Pruritus	0		Mild	Possibly	0
Fatigue	0		1 (4%)		0		1 (1%)	0	0
Fatigue	0		Mild	Unlikely	0
Feeling Hot	0		0		1 (2%)		1 (1%)	0	1 (13%)
Feeling Hot	0		0		Mild	Possibly
Headache	3 (33%)		2 (8%)		4 (9%)		9 (11%)	1 (7%)	2 (25%)
Headache	2x Mild 1x Moderate	2x Probably1x Possibly	1x Mild 1x Moderate	1x Probably 1x Possibly	2x Mild 2x Moderate	4x Probably
Hyperhidrosis	1 (11%)		0		0		1 (1%)	0	0
Hyperhidrosis	Mild	Possibly	0		0
Myalgia	1 (11%)		0		3 (7%)		4 (5%)	2 (14%)	1 (13%)
Myalgia	Mild	Possibly	0		3x Mild	1x Probably 2x Unlikely
Nausea	0		2 (8%)		2 (4%)		4 (5%)	1 (7%)	0
Nausea	0		2x Mild	2x Probably	2x Mild	2x Probably
Papule	0		2 (8%)		0		2 (3%)	0	0
Papule	0		2x Mild	2x Possibly	0
Paresthesia	2 (22%)		6 (25%)		10 (22%)		18 (23%)	0	0
Paresthesia	2x Mild	2x Probably	6x Mild	6x Probably	10x Mild	9x Probably 1x Possibly
Paresthesia Oral	0		3 (13%)		8 (17%)		11 (14%)	0	0
Paresthesia Oral	0		3x Mild	3x Probably	8x Mild	8x Probably
Pharyngeal Paresthesia	0		0		3 (7%)		3 (4%)	0	0
Pharyngeal Paresthesia	0		0		3x Mild	3x Probably
Productive Cough	0		0		1 (2%)		1 (1%)	0	0
Productive Cough	0		0		Mild	Possibly
Pruritus	0		1 (4%)		2 (4%)		3 (4%)	0	0
Pruritus	0		Mild	Possibly	2x Mild	2x Possibly
Rash Erythematous	0		0		1 (2%)		1 (1%)	0	0
Rash Erythematous	0		0		Mild	Possibly
Tachycardia	1 (11%)		0		0		1 (1%)	0	0
Tachycardia	Mild	Possibly	0		0
Throat Tightness	0		0		1 (2%)		1 (1%)	0	0
Throat Tightness	0		0		Mild	Probably
Vessel Puncture Site Pain	0		1 (4%)		0		1 (1%)	1 (7%)	0
Vessel Puncture Site Pain	0		Mild	Unrelated	0
Wheezing	0		0		1 (2%)		1 (1%)	0	0
Wheezing	0		0		Mild	Possibly

^a TTX is abbreviation for tetrodotoxin; ^{b, c} For each TTX-related AE, the corresponding results for moxifloxacin and placebo groups were included for comparison; ^d TEAE is abbreviation for treatment emergent adverse events.