Table 3.
Plasma tetrodotoxin pharmacokinetics parameters.
| Parameters | 15 µg TTX a (n = 9) |
30 µg TTX (n = 9) |
45 µg TTX (n = 9) |
|---|---|---|---|
| AUC0–∞ (h × ng mL−1) | |||
| Geometric Mean | 1.9612 | 4.0094 | 6.4983 |
| Geometric (CV%) | (31.8) | (17.6) | (10.0) |
| Cmax (ng mL−1) | |||
| Geometric Mean | 0.3046 | 0.5807 | 0.9914 |
| Geometric (CV%) | (30.3) | (17.4) | (16.2) |
| Tmax (h) | |||
| Median | 1.50 | 1.50 | 1.50 |
| (Min, Max) | (1.00, 2.00) | (1.00, 1.51) | (1.00, 2.00) |
| t½ (h) | |||
| Arithmetic Mean | 4.62 | 4.54 | 4.28 |
| Standard Deviation | (±1.84) | (±0.39) | (±1.35) |
a TTX is abbreviation for tetrodotoxin.