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Slope and intercept from the exposure-response analysis of ΔΔQTcF by tetrodotoxin treatment.
| Treatment | Geometric Mean Cmax (ng mL−1) |
Predicted ΔΔQTcF (ms) (90% CI) |
Model Slope (ms (ng mL−1)−1) (90% CI) |
Model Intercept (ms) (90% CI) |
|---|---|---|---|---|
| 15 µg TTX a | 0.3046 | 0.285 (−0.255, 0.825) |
−1.378 (−3.266, 0.510) |
−0.705 (−0.131, 1.540) |
| 30 µg TTX | 0.5807 | −0.096 (−0.798, 0.607) |
||
| 45 µg TTX | 0.9914 | −0.661 (−2.003, 0.680) |
a TTX is abbreviation for tetrodotoxin.
