Figure 8.
In vivo antiviral activity of Cmp 4 against LCMV. (A) Structural formula of Cmp 4 (IMU90838, also known as vidofludimus calcium). (B and C) C57BL/6 mice (n = 4) were orally treated with Cmp 4 (150 mg/kg/d) for 17 days or with VC. Both groups of mice were infected (IV) with 2 × 106 pfu of CL-13. Body weight changes (B) and serum virus titers (C) were determined at the indicated time points. Statistical significance was calculated by ANOVA (* p < 0.05, ** p < 0.002, and **** p < 0.00001).