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. 2020 Aug 13;12(8):883. doi: 10.3390/v12080883

Figure 2.

Figure 2

Adaptive mutations in the GZCII-P30 genome revealed by Next-Generation Sequencing were mapped onto the EV71 capsid. (A) Genomic RNA of the GZCII and GZCII-P30 viruses was sequenced by NGS, and the mutation frequency and distribution were analyzed according to the reference sequence (cGZCII). The open symbols represent nonsynonymous mutations, and the closed symbols are synonymous mutations. Red: GZCII-P30; Blue: GZCII. (B) A 3D structure of the GZCII-P30 virus was predicted by SWISS-MODEL homology modeling based on PDB:3VBF.1. VP1-E92K and E98K reside at the 5-fold axis, while VP2-I149V is located in the E-F loop on VP2. Blue: VP1; red, VP2; green, VP3; yellow, VP4.