Table 3.

Summary of key clinical points of two studies.

Main Data	Tacket et al. 1984 [48]			Lonati et al. 2015 [50]
Study Period	1973–1980			2007–2013
BoNT Involved	Bont A			BoNT B (63%), BoNT A (9%), BoNT BF (2%), BoNT AB (1%); not Identified in 25% of Cases
n° of patients	134			98
	n° of patients treated with antidote		no antidote	n° of patients treated with antidote		no antidote
	115 (87%)		17 (13%)	59 (60%)		39 (40%)
time of antidote administration	<24 h	>24 h	–	<24 h	>24 h	–
orotracheal intubation (OTI)	n.a.	n.a.	n.a.	26%	53.8%	7.6%
duration of OTI (days)	n.a.	n.a.	n.a.	13.6 ± 5.6	21 ± 15.5	n.a.
median hospital stay (days)	10	41	56	n.a.	n.a.	n.a.
fatality rate	10%	15%	46%	0%	1% *	0%

note: * BoNT-B, female 89-year-old, severe comorbidity. n.a.: not available.