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. 2020 Aug 5;12(8):502. doi: 10.3390/toxins12080502

Figure 4.

Figure 4

Effect of AST-120 on adipocyte inflammation in 5/6-nephrectomized CKD mice. After randomization at 4 weeks after nephrectomy, the AST-120-administered group was fed a diet containing 8% AST-120 for 24 weeks. Effect of AST-120 on IS levels in (A) plasma and (B) epididymal adipose tissue of 5/6-nephrectomized CKD mice. Immunofluorescent staining of (C) IS (green), nitrotyrosine (Nitro-Tyr: red)) and F4/80 (green) in epididymal adipose tissue of CKD mice. Original magnifications: ×200. Scale bars represent 100 μm. (D) MCP-1, (E) F4/80 and (F) TNF-α mRNA expression in epididymal adipose tissue were determined by quantitative RT-PCR. Data are expressed as means ± SE (n = 4). * p < 0.05 compared with sham; # p < 0.05 compared with CKD.