Table 4.
The microRNAs with most frequently conserved target sequences in the 3′UTRs of hepatitis C virus (HCV) and hepatitis E virus (HEV) and their amplification status in pre- (P1.1) and post-treatment (P1.2) samples.
| microRNAs Targeting HCV 3′UTR * | microRNAs Targeting HEV 3′UTR * | ||||
|---|---|---|---|---|---|
| hsa-miR- | Frequency of Target Sequence ** | Amplification in P1.1 and P1.2 | hsa-miR- | Frequency of Target Sequence ** | Amplification in P1.1 and P1.2 |
| 122 | 33 | ↓in P1.2 | 298 | 9 | Not amplified in either |
| 505-5p | 17 | Failed to amplify in P1.2. Not included | 539-5p | 6 | 539 no significant change |
| 651-3p | 14 | Not amplified in either | 328-5p | 5 | 328 no significant change |
| 548 family | 9 | 548c ↓ in P1.2 | 548 family | 4 | 548c ↓ in P1.2 |
| 1252-5p | 8 | 1252 no significant change | |||
| 939-5p | 4 | 939 no significant change | |||
| 509-3/5p | 4 | No significant change | |||
* Only microRNAs included in TaqMan array cards A and B are shown. ** Those with four or more targets among the 35 HCV and 39 HEV complete genomic sequences are shown. Accession numbers of the analysed sequences are shown in Supplementary Table S2.