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. 2020 Jul 31;12(8):842. doi: 10.3390/v12080842

Figure 2.

Figure 2

Regulation of Gag binding to the plasma membrane (PM). (a) Interactions of Gag with PI(4,5)P2 and tRNA ensure specific localization of Gag to the PM. Binding of Gag to tRNA prevents localization of Gag to intracellular membranes that contain PS but not PI(4,5)P2. Interaction of Gag with PI(4,5)P2-containing membrane overcomes the block on membrane binding by tRNA, thereby recruiting Gag to the PM; (b) cholesterol-dependent membrane binding by Gag. Cholesterol increases the membrane binding of Gag, including binding to PI(4,5)P2-containing PM.