Table 1.
Genetic differences between the parental tick-borne encephalitis virus (0 P) and individual new variants (40 PS, 40 IRE, and LT IRE) based on a comparison of full genome sequences. (UTR stands for “untranslated regions”)
| Genome Region | Nucleotide Substitution | Amino Acid Substitution | ||
|---|---|---|---|---|
| Substitution | TBEV Variant | Substitution | TBEV Variant | |
| 5′ UTR | G (52) → A | 40 IRE | ||
| Protein C | A (315) → G | 40 IRE | ||
| Protein prM | C (101) → T | 40 IRE | Thr (34) → Ile | 40 IRE |
| Protein E | A (913) → G | 40 PS | Thr (305) → Ala | 40 PS |
| C (1078) → T | 40 PS | Pro (360) → Ser | 40 PS | |
| A (1411) → T | LT IRE | Met (471) →Leu | LT IRE | |
| Protein NS1 | G (169) → A | 40 IRE | Val (57) → Ile | 40 IRE |
| G (237) → A | 40 PS | |||
| Protein NS2A | T (605) → C | 40 PS | Val (202) → Ala | 40 PS |
| Protein NS2B | G (97) → A | 40 IRE | Val (33) → Met | 40 IRE |
| Protein NS3 | T (978) → C | 40 PS, 40 IRE | ||
| A (1314) → G | LT IRE | |||
| Protein NS4B | C (240) → T | 40 PS | ||
| G (253) → T | 40 IRE | Ala (85) → Ser | 40 IRE | |
| T (262) → A | 40 PS | Phe (88) → Ile | 40 PS | |
| Protein NS5 | G (333) → A | 40 PS, 40 IRE | ||
| A (529) → C | LT IRE | Thr (177) → Pro | LT IRE | |
| C (2332) → T | 40 PS | Leu (778) → Phe | 40 PS | |
| A (2588) → G | 40 PS | Asn (863) → Ser | 40 PS | |
| 3′ UTR | T (282) → C | 40 PS, 40 IRE | ||