Table 5.
Diet | LM | HM | SEM | p Value | ||||
---|---|---|---|---|---|---|---|---|
PYCW | 0% | 0.2% | 0% | 0.2% | Diet | PYCW | Diet vs. PYCW | |
Villus width, µm | 420.9 | 432.4 | 401.9 | 407.7 | 7.1 | 0.263 | 0.684 | 0.611 |
Villus height (V), µm | 153.2 | 157.7 | 161.2 | 160.7 | 19.8 | 0.100 | 0.512 | 0.826 |
Crypt depth (C), µm | 214.0 | 223.4 | 203.4 | 203.5 | 11.6 | 0.045 | 0.522 | 0.527 |
V:C | 2.00 | 1.97 | 2.02 | 2.04 | 0.14 | 0.651 | 0.932 | 0.785 |
Ki-67 proportion, % | 25.93 | 25.61 | 27.27 | 27.44 | 2.40 | 0.343 | 0.963 | 0.882 |
1 Ki-67 is an estimate of the proliferative rate, calculated based on the proportion of cells positive to Ki-67 staining (immunohistochemistry) to the total number of cells in the crypt. 2 HM has 1.0 μg/kg of AFB1 and 2258 μg/kg of DON on average for phases 1 and 2, and 44.6 μg/kg of AFB1 and 4635 μg/kg of DON for phase 3.