Table 1.
Clinical and biological characteristics of BKPyV Controller and Non-controller groups. For continuous variables, mean ± standard deviation are shown for each group. Means were compared by unpaired Student t-test, and categorical variables were compared by Fisher’s exact test.
| Controllers (n = 12) |
Non-Controllers (n = 12) |
p | |
|---|---|---|---|
| Age (years) | 56.2 ± 14.5 | 50.4 ± 12.8 | 0.308 |
| Sex (M/F) | 7/5 | 10/2 | 0.371 |
| Kidney donor deceased/living |
12/0 | 9/3 | 0.217 |
| Cold ischemia time (hours) all donors | 17.9 ± 6.6 | 8.7 ± 4.8 | <0.001 |
| Cold ischemia time (hours) deceased donors | 17.9 ± 6.6 | 10.9 ± 3.2 | 0.008 |
| Number of HLA mismatches | 2.7 ± 1.5 | 4.1 ± 1.4 | 0.028 |
| Induction therapy Basiliximab/ATG |
9/3 | 7/4 | 0.667 |
| Immunosuppressive regimen base MMF or MPA plus Tacrolimus | 12 | 11 | 1.000 |
| Maintenance immunosuppression included corticoids | 6 | 8 | 0.680 |
| Modification of immunosuppressive regimen following BKPyV reactivation | 7 | 10 | 0.371 |
| Received IVIG post graft | 2 | 0 | 0.478 |
| Rejection within 12 months post-graft | 1 | 1 | 1.000 |
| Months post-graft at first positive viruria | 2.9 ± 2.5 | 3.5 ± 2.9 | 0.606 |
| Peak viruria (Log10 copies/mL) | 8.8 ± 1.0 | 8.8 ± 1.1 | 0.947 |
| Viremia positive | 9 | 10 | 1.000 |
| Peak viremia (Log10 copies/mL) | 3.7 ± 1.0 | 4.4 ± 1.2 | 0.238 |
| Confirmed PyVAN | 3 | 6 | 0.400 |
| BKPyV genotype I/IV | 12/0 | 10/2 | 0.478 |