Fig. 1. PI3Kα conformation and oncogenic mutations. (A) PI3Kα sequence and the frequent oncogenic mutations in p110α (data obtained from TGCA database). (B) PI3Kα structures (PDB ID 4OVV) with the oncogenic mutations highlighted by the red surfaces. The close-up of (C) the PI3Kα conformation with nSH2 in the crystal structure (PDB ID ; 4OVV), (D) the conformation of PI3Kα with nSH2 released from the simulations,15 and (E) the conformation of the PI3Kβ with nSH2 released (PDB ID ; 2Y3A).