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. 2020 Aug 21;7:430. doi: 10.3389/fmed.2020.00430

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Copyright © 2020 Bordignon, Luisetto, Valente, Fedrigo, Castellani, Angelini and Alaibac.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Melanoma inhibitory activity (MIA)-related pathogenesis of vitiligo. Mechanism of action of MIA in melanocytes leading to vitiligo. (A) Normal adhesion of melanocyte attached to the basal membrane, mediated by alpha5beta1 integrins. (B) Vitiligo disease: melanocyte is attacked by MIA, which binds to alpha5beta1 integrins. (C) After the binding of MIA with alpha5beta1 integrins, the presence of other precipitating factors as oxidative stress, physical trauma, or autoantibodies initiates the detachment of the melanocyte. (D) Complete detachment of melanocyte and formation of vitiligoid patches on the skin. Modified from Bordignon et al. (2).