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. 2020 Aug 21;7:430. doi: 10.3389/fmed.2020.00430

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Copyright © 2020 Bordignon, Luisetto, Valente, Fedrigo, Castellani, Angelini and Alaibac.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of injection of melanoma inhibitory activity (MIA) or saline in the tail of mice. (A) Control group—injection of saline, with absence of any depigmentation and normal-appearing skin. (B) Group 1 and (D) group 3—injection of MIA 1% in saline, with the appearance of a wide and complete area of depigmentation in the treated zones, without any signs of damage or alteration of mice skin. (C) Group 2—injection of MIA 1% in saline, with the appearance of an incomplete area of depigmentation in the treated zones without any signs of damage or alteration of mice skin.