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. 2020 Aug 21;11:978. doi: 10.3389/fphys.2020.00978

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Copyright © 2020 Song, Zhang, Hu, Zhang, Cao, Liu, Zhang and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of Cur on L-type calcium current (I_Ca.L) in ventricular myocytes. (A) Example records I_Ca.L in different membrane potentials for the control group and Cur (5, 10, 20, and 30 μmol/L) groups. (B) The current–voltage (I–V) relationship curves of Cur on I_Ca.L (n = 8, ^€P < 0.05, ^€€P < 0.01, ^€€€P < 0.001 vs. control; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs. 5 μmol/L; ^&P < 0.05, ^&&P < 0.01, ^&&&P < 0.001 vs. 10 μmol/L; *P < 0.05, **P < 0.01, ***P < 0.001 vs. 20 μmol/L). (C) The concentration–response relationship curve of Cur on I_Ca.L. (D) Example records of the single I_Ca.L from the same cell of three groups (control group, 10 μmol/L Cur group and wash out group), showing a reversible inhibitory effect of Cur on I_Ca.L. (E) The comparison of average I_Ca.L percentage values of the three groups (n = 6, P < 0.001 vs. control; ^†††P < 0.001 vs. 10 μmol/L Cur). (F) Example records of steady-state inactivation of I_Ca.L before and after administrating 30 μmol/L Cur. (G) Steady-state activation and inactivation curves of two groups. (H) Example records of time-dependent recovery of I_Ca.L before and after 30 μmol/L Cur administration. (I) Time-dependent recovery curves of the two groups.

Inline graphic — The effects of Cur on L-type calcium current (I_Ca.L) in ventricular myocytes. (A) Example records I_Ca.L in different membrane potentials for the control group and Cur (5, 10, 20, and 30 μmol/L) groups. (B) The current–voltage (I–V) relationship curves of Cur on I_Ca.L (n = 8, ^€P < 0.05, ^€€P < 0.01, ^€€€P < 0.001 vs. control; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs. 5 μmol/L; ^&P < 0.05, ^&&P < 0.01, ^&&&P < 0.001 vs. 10 μmol/L; *P < 0.05, **P < 0.01, ***P < 0.001 vs. 20 μmol/L). (C) The concentration–response relationship curve of Cur on I_Ca.L. (D) Example records of the single I_Ca.L from the same cell of three groups (control group, 10 μmol/L Cur group and wash out group), showing a reversible inhibitory effect of Cur on I_Ca.L. (E) The comparison of average I_Ca.L percentage values of the three groups (n = 6, P < 0.001 vs. control; ^†††P < 0.001 vs. 10 μmol/L Cur). (F) Example records of steady-state inactivation of I_Ca.L before and after administrating 30 μmol/L Cur. (G) Steady-state activation and inactivation curves of two groups. (H) Example records of time-dependent recovery of I_Ca.L before and after 30 μmol/L Cur administration. (I) Time-dependent recovery curves of the two groups.