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. 2020 Aug 21;11:978. doi: 10.3389/fphys.2020.00978

FIGURE 3.

FIGURE 3

The effects of Cur on transient sodium currents (INa.T) and late sodium currents (INa.L) in ventricular myocytes. (A) Example records of the single INa.T of control group and Cur (30, 100, 200, 400, and 600 μmol/L) groups. (B) The concentration–response relationship curve of Cur on INa.T. (C) Example records of different concentrations of Cur on the basal endogenous INa.L. (D) The concentration–response relationship curve of Cur on the single basal endogenous INa.L. (E) Example records of INa.L of control, ATX II, and TTX groups. (F) Example records of ATX II increased-INa.L at membrane potentials of −80, −60, −50, −40, and −20 mV from the same cell for the control group, ATX II group, and Cur groups (1, 5, and 10 μmol/L). (G) The I–V relationships curves for the effects of Cur on ATX II-increased INa.L (n = 11, *P < 0.05, ***P < 0.001 vs. control; &P < 0.05, &&P < 0.01, &&&P < 0.001 vs. 10 nmol/L ATX II; €P < 0.05, €€P < 0.01, €€€P < 0.001 vs. 1 μmol/L Cur; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. 5 μmol/L Cur). (H) Example records of single INa.L showing a reversible inhibitory effect of Cur on ATX II-increased INa.L. (I) The comparison of average INa.L percentage values of the three groups (n = 8, #P < 0.05, ###P < 0.001 vs. control; &&&P < 0.001 vs. 10 μmol/L Cur).