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. 2020 Aug 21;11:978. doi: 10.3389/fphys.2020.00978

FIGURE 4.

FIGURE 4

Effects of Cur on rapidly delayed rectifying K+ currents (IKr) in ventricular myocytes. (A1–A5) Example records of Cur on IKr in different membrane potentials for the control group and Cur groups (1, 5, 10, and 15 μmol/L). (B) The I–V relationships curves for the effects of Cur on IKr–tail (n = 15, €€P < 0.01, €€€P < 0.001 vs. control; #P < 0.05, ###P < 0.001 vs. 1 μmol/L Cur; &P < 0.05, &&P < 0.01, &&&P < 0.001 vs. 5 μmol/L Cur; **P < 0.01, ***P < 0.001 vs. 10 μmol/L Cur). (C) The concentration–response relationship curve of Cur on IKr–tail, fitted with a Hill function. (D) Example records of single IKr showing a reversible inhibitory effect of Cur on IKr–tail. (E) The comparison of average IKr–tail percentage values of three groups (n = 8, ***P < 0.001 vs. control, &&&P < 0.001 vs. 10 μmol/L Cur).