Table 2.
Electrophysiological parameters of part 2 (n = 21).
| Baseline | Dofetilide | |||||
|---|---|---|---|---|---|---|
| Total (n = 21) | I (n = 11) | NI (n = 10) | Total (n = 21) | I (n = 11) | NI (n = 10) | |
| RR (ms) | 1,186 ± 255 | 1,263 ± 229 | 1,102 ± 267 | 1,197 ± 257 | 1,274 ± 219 | 1,111 ± 266 |
| QT (ms) | 395 ± 57 | 403 ± 59 | 387 ± 56 | 569 ± 72* | 578 ± 76* | 560 ± 75* |
| QTc (ms) | 379 ± 59 | 380 ± 61 | 378 ± 59 | 522 ± 70* | 554 ± 70* | 550 ± 71* |
| ARI (ms) | 296 ± 49 | 309 ± 52 | 282 ± 44 | 411 ± 88* | 443 ± 85* | 375 ± 80* |
| STVARI slope (ms) | 1.44 ± 1.04 | 1.69 ± 1.33 | 1.15 ± 0.49 | 3.57 ± 2.75* | 5.09 ± 3.07* | 1.90 ± 0.64§ |
| STVARI FSA (ms) | 1.14 ± 0.68 | 1.20 ± 0.88 | 1.08 ± 0.42 | 2.41 ± 1.25* | 3.11 ± 1.30* | 1.63 ± 0.57§ |
| STVARI automatic (ms) | 1.00 ± 0.58 | 1.02 ± 0.63 | 0.98 ± 0.54 | 1.93 ± 0.95* | 2.51 ± 0.96* | 1.30 ± 0.33§ |
Data expressed as mean ± SD in ms.
*
p < 0.05 compared to baseline.
§
p < 0.05 compared to inducible subject after dofetilide administration.