Figure 2.

Lethality in five inbred mouse strains following RVFV infection. (A) Survival curves of five inbred mouse strains infected via footpad injection with wild-type RVFV at doses of 0.2 or 2 TCID₅₀ show dose-dependent differences in time to death but not survival. Each line represents the percent survival after infection of female and male mice at a given challenge dose. Confirmed uninfected mice from the 0.2 TCID₅₀ dose are excluded from the graphs. (B) Percent survival of all five inbred mouse strains when infected with 2 TCID₅₀ RVFV. Each line represents the percent survival after infection of five female and five male mice for a given strain. (C) Percent change in mouse daily weight from baseline in all five inbred strains after infection with 2 TCID₅₀ RVFV. Weight loss curves represent five female and five male mice for a given strain. Survival statistics were calculated using a log rank (Mantel-Cox) test and p are marked on all graphs. The mixed-effects model with the Geisser-Greenhouse correction were used for weight loss comparisons between mouse strains over time.